#380: Unlocking The Fountain of Youth: The Proven Science Behind Age Reversal Secrets with Carolina Oliveira Co-founder & CEO at OneSkin

There was a point in my life that I was using like six products and my skin was completely messed up and I couldn't like go to the corner outside without makeup. And now I basically wake up and I wash my face. I put, you know, the two ones in the face, the eye and the sunscreen and I feel so good. I just look at the mirror. This is going to feel so healthy and glowy.

Come on this journey with me each week when you join me, you're going to chase down our goals, overcome adversity and set you up for a better tomorrow.

I'm ready for my close up.

Hi and welcome back. I'm so glad you're here this week with us now. You know, so rarely do I ever have a guest on twice. But today we have Carolina Oliveira, the CEO and co founder of OneSkin, back on a second time and I'm going to break down for you why. She holds a PhD in stem cell biology and tissue engineering, is a co inventor of five patents and co author of numerous scientific publications. She is the real deal. She relocated from Brazil to Silicon Valley in 2016 to found One Skin, the fastest growing longevity company. In my book, developing products promote skin age reversal by targeting a central driver of aging, the accumulation of senescent cells. Carolina and her team are disrupting the outdated anti aging skin care industry with their groundbreaking research around skin and longevity. Carolina, thank you so much for coming back on the show today.

Yeah, thanks for having me again, Heather.

Okay, so I begged you to come back on because I've now been on your products for five months and I told you this off air. It's so crazy and I want the best for everybody. Like so this can't be the world's best kept secret. My skin has never looked better in the last few years. That's not my opinion. I do feel that way. That's my dermatologist who is not affiliated with One Skin at all, told me that when I went into his office. He's also a dear friend of mine and he was so interested in One Skin and the testimonial I gave him, he went down the rabbit hole and said the research is incredible. The science behind it, it's incredible. And he said, listen, I need to talk to these people. And he started discussions with you guys because he was so interested as well in the line. And Carolina, I also just saw you came out as Glamour's 2023 Best Beauty and wellness innovator with your eye product. I mean to me it's like One Skin is something that everybody needs to know about these days. Aren't you feeling that it's just exploding?

Yeah. It's funny how, you know, it's definitely building momentum. I think many years of research and very solid and rigorous work is now coming up with so many people recognizing the results that they are seeing with their products and the clinical studies that are backing up all of our science. And even from the PR side, having this recognition is super exciting because this is literally seven years of really hard work. It takes a village to build something that's really groundbreaking. We are just starting. There's so much more to come.

I'm so excited and I'm so here for all of it. Okay, so for people who missed the first episode, if you haven't heard Carolina's first episode, please go back and listen to the whole story behind One Skin, which is such a great business story and an inspiring one as well. But can you share a little bit about the technology, the science behind what one Skin is all about?

Yeah. So the main innovation of One Skin products is this novel peptide that we found. And for those who don't know what's a peptide. Peptides basically a small version of a protein. And this peptide can have different functions in our bodies. The one that we found is completely novel, is completely unique in a way that it functions. So we found that this peptide to be able to reduce the amount of old cells in our skin. Also called senescent or zombie cells. These are cel have accumulated in our skin. As we get exposed to UV damage to pollution. All these environmental stresses lead to damage that leads to the buildup of those zombie cells. So what those zombie cells do in our skin, they secrete inflammation that basically leads to collagen breakdown. And this leads to wrinkles, sagging, dark spots, all the things that we don't want. So our strategy is very interesting because we knew that these cells were like driving ag and inner layers of our skin. So we searched for a new peptide that could basically activate our cells ability to repair damage more efficiently so we don't accumulate too many of those zombie cells. And in the studies that we found, we could validate that by reducing the amount of zombie cells in the skin, we allow the healthy skin cells to replicate again so they can produce more collagen. They basically rejuvenate their skin from the inside out. So your skin is like healthier. It looks younger too, but in a very safe way, doesn't cause any side effects. Like very different from other products in the market, like retinol or acids. That you know, can peel off the upper layers of your skin, you have a smoother skin, but you are not addressing what's causing aging underneath. The other cool data that we have with this peptide, when we treated this, the skins in the lab is that we could measure that it reverses the age of the skin so we can quantify how many years we are actually reducing the age of the skin. And in the lab we saw that we could reduce 2.5 years the age of the skins that were treated with this peptide. And then in humans, we also did a study in humans. So basically these are people that have used the product for 12 months and we needed to collect a skin biopsy and we could measure the age reversal and we could see a decrease of 3.3 years in the skin of those participants. So this is very revolutionary that now we can validate that we can actually reverse the age of the skin in humans. And what that means for, you know, our consumers, our users, is that using our product you are not going to have a skin that's biologically younger functions like younger skin. It looks like younger as well. It looks like smoother and it looks firmer. It has a stronger skin barrier which is super important for longevity, for our overall health. So yeah, in a nutshell, that's a little bit of how our product works.

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Article from a biohacker I'm trying to think Nick Engineer.

Yeah, yeah, PhD.

I noted he had written a pretty detailed article about him doing his own research which I love because of course companies always come out with their information and you always as a consumer, you know this too. We always wonder. I don't have a PhD. I can't question anything but I like seeing that he did his own research. Can you talk to us a little bit about the different way that he did his research and the massive results that he saw which were even bigger than the results that you brought forward.

Yeah, we love when our customers do that. So we have a lot of those very savvy and people that like to run their own experiments. So Nick is one of them. So basically he bought our products, he went to a clinic and he got a VISA scan. So this VISA scan, it's basically an imaging a very sophisticated imaging system that can see beyond what we can see at our naked eye, can see pores, you can see some damage. And in the end, what the software does, it gives you like a skin age. So when he started, I think if I'm not wrong, his age was 41 years old. And he saw that they had a lot of sun damage and obviously he could see the fine lines and wrinkles. And he used one skin for five months and then he went back to the same clinic and got those images again. You know, the difference on the skin. Age reversal was like from 41 to 35 or 34. I remember that was seven years like age reversal that he saw in his own experiment. But also he saw decrease in sun damage. He saw improvement in fine lines and wrinkles. And everything is quantitative, which I love because it's not like his own, like perception. Oh, I feel that, you know, my skin is looking better. This machine allows you to quantify like you're improving 35%, you're improving, you know, whatever amount. That's the kind of data that we love because we believe that we can rely much better on those data than like the subjective perception that a lot of companies use because it's easier to get some data this way. But yeah, we were really happy. And we have other people like him, biohackers or scientists that they like to do this kind of experiment. And we actually incentivize people to do that because we want to get as much data as possible. And we know that the best way is actually to be able to quantify. And for that you need like some more sophisticated machine or, you know, images system.

Well, I love that number seven years that he shared. I was like, this is okay, now we're talking. And for everyone listening, I mean, truly, this is a third party doing their own data analysis. Someone with a PhD that's finding one skin to reverse his aging by seven years. This product line reverses your skin's aging. I mean, everyone's going to buy some skin product. Why not buy the only one on the market that it's scientifically proven to reverse your skin's aging. It's to me a no brainer. So one of the things that I would assume if I had never used this product line before, Carolina, is it's going to be 24 pieces that I have to get. And you know, and I remember when Kim Kardashian launched her skin line, people were saying that there's all these different elements or if you're using a retinol, then you have to use this. Can you talk about how your line can be so simple yet so powerful.

Yeah, we have a very clear rationale how we develop our products and how they work. So because of that, we can simplify the amount of products that you need. And we try, you know, to think on the consumer and even myself, like, I don't have time to use 10 steps, 10 products on my skincare routine. We want to obviously be efficient. We want to be cost, you know, efficient. So we basically created like very few products that can deliver the results that you need. So the first one is a facial cleanser. It's a very gentle cleanser that doesn't disrupt your skin. Microbiome is going to remove like the impurities without drying out your skin. And and then you apply the face moisturizer that contains the peptide you can apply on your whole face, neck and hands, like twice a day. And then you have an eye product that we develop specific for the eye area, because the skin around our eyes is thinner, ages faster. So we develop this formula that has a higher concentration of the peptide. So this is the most potent product among all of our one skin products because we need more help around our eyes. And on top of that, you add like a sunscreen, it's a mineral. One also contains the peptide and has other five antioxidants that really helps combating, like the free radicals. So very simple. In less than five minutes, you can do it. The other piece that we didn't forget, and I think it's important to remind everyone, is to treat your whole body, right? Like, our skin needs to be treated as an organ. And we can't forget the skin of our body because when we start seeing like crepiness or our skin start to get thin and bruising easily, we'll see. Okay, maybe I should have taken more care of, you know, of my body, not only my face. So that's why we created this body lotion that hydrates your skin in a very nice way without leaving it greasy and helps a lot with crepeness and increasing the thickness of the your skin as well. And people that already have like a very thin skin have seen great improvement in terms of building the skin, like resilience. So because of that, we are very intentional with the products that we have, and we want to make it easier for our customers and make sure that they can feel good, you know, with like a simple, effective and gentle skincare routine.

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For anyone listening right now, that has fair skin. I'm your person. I'm like a glass of milk. And to what you said Carolina, My skin just naturally is thin before I was even in my 40s. I'm 49 now. My skin is definitely thin. And the funny thing is in the last year, just in my 49th year, I started noticing the skin on my upper legs was looking weird and the same. I discussed it with my girlfriends and they're like our skin's creepy now. My friends that have more Mediterranean type, you know, darker skin, not as much with them, that hadn't been an issue for them. They had other issues. They felt their hands were, you know, didn't look the way they want. They had other problems. We all have our own problems. But once we started talking about that creepy skin, it was only a couple months before I started using one skin that is gone. The two biggest results I've had thus far in five months, number one, around my eyes that was, I mean just game changing to me, very, very noticeable at the two month mark is when I really started noticing there's a difference here. Now I see a much bigger difference. But the other thing is the skin on my legs and my chest and neck where it's definitely I started noticing a creepiness. So no matter what your issue may be, use the product. You will see you have a 45 day money back guarantee. Isn't that right?

We do. If it doesn't work for you for any reason, we definitely will refund you. But Definitely. We believe so much in the science in all these studies that we've done with this products that it should work for most of you. And we guarantee that we are improving the health of your skin and the results will come. So for some people will come with like two, three weeks. Some people can take like three months. All of our clinical studies, the most significant data, it's after 12 weeks, so around three months. So we just ask people to be consistent, to be, I would say, you know, patient in some ways, because we want to make this change from the inside out. It's not just a band aid. It's something that's really helping your skin to be stronger. So it can take more time for a few people, but it's definitely worth it, the weight and the investment.

Well, thanks for bringing that point up because for me, the only way I got visible results in the past was from doing a laser. And the problem with a laser is, to your point, it wasn't fixing anything for the long term. It was a short term fix. Peel off the skin. And so it would look nice for a couple of months, but. But then inevitably that was it. There was no long term benefit. It wasn't improving the health of my skin. It was costing a fortune. And there was downtime, both of which are gone. With one skin, not only am I healing my skin, improving my body from the inside out, there's zero downtime. And you're not laying out thousands of dollars to see a one time benefit.

Yeah, that's it. It can be simple.

Who knew where was this product years ago? So let' talk a little bit about SHIELD Because I'm a runner. I also happen to live in Florida. Right. So I know a lot of people don't believe this. I'm from Boston and so many of my friends don't wear sunscreen every day. I do because I live in Miami. So I'm aware that you need. But what can you tell us about the importance of sunscreens versus the one skin shield?

Yeah, so first of all, the main factor that's behind skin aging, it's UV damage. So this is a consensus. So for everyone that's looking to prevent aging or reverse aging, sunscreen should be a part of their skin care routine. That doesn't mean that you can take like, you know, five, 10 minutes in the morning without sunscreen to get, you know, that light from the sun. But if you are out for like hours, and if you are, you know, when the UV index is above 3, you should be wearing sunscreen. Now there Are different types of sunscreen out there. There are the chemical ones which can, you know, get into your bloodstream and also can cause more irritation. So it's not like the safest, and obviously, even for sustainability, can compromise brief corals. And so it's not the approach that we recommend. And they are the physical or the mineral ones. And among the mineral ones, the best option that, again, it's more adequate for all skin types is the zinc oxide. That is not gonna cause irritation. Sensitization. So ours has zinc oxide. And the main problem of zinc oxide is that a lot of them can leave a white cast. Right. Who doesn't haven't applied a sunscreen that feels all white out of ascendant? And that's why a lot of people don't like sunscreen, because the experience used to be so bad. But technology has evolved, and we are now able to formulate much better formulas that, with a nice texture that can deliver the protection without leaving a white cast. So one skin has developed this sunscreen that contains the peptide. So not only offers the protection, so it's a 30 plus SPF, but also has a peptide in case we don't reapply as we should, and then we get a little bit of sun damage. The peptide is there to help repair potential sun damage that you get on a daily basis. And on top of that, we also added five antioxidants. So, for example, a lot of people want to use vitamin C in their skincare routine. This sunscreen has a very stable form of vitamin C. So we're covering your antioxidants with the sunscreen. And but on top of that, we have green tea, we have acai extract. So very powerful antioxidants that will help combating, like, free radicals. And the best thing. And I think you can share the texture. It's so amazing. You apply, and it feels that you're applying another layer of moisturizer. I love the tinted one. Gives me, like, a nice glow. It doesn't give you coverage. It just, like smooths out your skin tone. And then, yeah, your skin is ready if you want to apply some makeup on top. If not, you're basically kind of, you know, done for the day. So that's one of my favorite products right now because it feels that I'm nurturing my skin with the sunscreen, which was before, like, almost hard to believe that I couldn't do that.

Incredible. And like you said, I just mix mine with my foundation in my hand before I apply it, and I'm set to go. And I use the tinted as well. Well, the tinted is incredible. Not sticky, nothing white. Nothing that you feel is different than any other makeup or moisturizer that you would put on. Yet you're putting the OS 01 peptide on your skin, healing your skin, which is such an incredible feeling. Do you get many comments from people that it helps with their confidence when they know they're doing something so good for themselves? They're looking better, they're feeling better.

Yes. So many reveals and testimonials, you know, for all of our products, but for people see incredible results. For the eye, I think the eye is the one that the people can see results the faster. But for the body, people said that, oh, I was not using sleeveless shirt anymore. Now I can go to work, and I'm so happy that I look at my arms and, you know, I feel good about them, or I was not using dress or, you know, skirts, and now my legs, like, I feel much more confident, so it's really rewarding. And people with some skin conditions as well, they start kind of, you know, to have a healthy skin in general, but they just, like, you know, feel that they don't need as much makeup anymore. And this is true for myself. There was a point in my life that I was using, like, six products, and my skin was completely messed up, and I couldn't, like, go to the corner outside without makeup. And now I basically wake up and I wash my face. I put, you know, the two ones in the face, the eye and the sunscreen, and I feel so good. I just look at the mirror like, this kid feels so healthy and glowy is the best part, actually, to kind of see the impact and how we are improving people's lives in so many ways, that's. For a scientist. This is the dream coming true. Is seeing your science really making a difference in, you know, people's lives.

When beauty comes from within, it's so powerful because you feel better about who you are and taking that next step forward, and it just makes you feel so much more confident. I feel the same way that you do. When I feel good about my skin, I feel so much better about everything. Now, not just women use this line, though. Correct. Don't men get the benefits just as easily as a woman?

Yeah, definitely. This product, this brand, is for everyone that cares about skin health and preventing or combating the signs of aging with safe and effective products. Because there are several ways that you can address aging that's not necessarily safe or good for your skin. But we have a lot of men that use our products. And one of the reasons that they give us a try, because a lot of men are skeptical about all these skincare products and all the crazy claims that out there. It's because we have data. We have data to back up every single claim. And men, they are starting to care more about their look and they feel like they need to take care of their skin as well. But they want to find a brand that they trust and I think one skin is one that has resonated really well with them also because, you know, our packaging is very gender neutral and we talk a lot about longevity and biohacking and health optimization. So that all aligns with, you know, that man mindset that they are always trying to improve their health in some ways but with legit like products.

Well, for people that are thinking about getting a holiday gift, stocking stuffers, they want to get someone something special. I wanted to show the minis that you now have, but you were also mentioning people can package and partner the minis together. How does that work?

Yeah, so in our website if you go to travel kit or travel size, you can find like mini bundles so you can give a gift of like face and eye iron. Prep Prep is the cleanser or face and body. This is a wonderful gift to introduce, you know, a friend or a family member to, to the brand and the chances that they love is really high. So very cost effective and you can already like make a huge, I'd say mark in their lives, make a literal.

Difference in somebody's life with this gift. So give the gift that's actually healing someone else. The line is safe, clean, vegan, cruelty free which I think is so important and the amount of give back work that you guys do is incredible. I also want to just show the travel kit. How cute is this? You have it in teal, coral and black. There's so many incredible options. It's so simple to do. And we've got a link in the show notes below. 15% off for everyone today. Buy now and buy on subscription like I did. That way you can get the discount all the way through and turn your skin into something you feel incredible about. Carolina, where can everyone find you on our obviously website?

I strongly suggest everyone to subscribe to our newsletter. We share so much about either new products but great content around the science, the studies and testimonials of our customers. Our community on Instagram @1Skin Co and our website is also oneskin co not.com we can't wait to welcome you guys to this beautiful community.

Well get the link in the show notes below. Put your orders in now so you get everything in time for the holidays to make a 2024 your best year yet. Carolina, thank you so much. And what I'm sure you're working on some new things that we're going to be excited to hear about next year.

Yes. I can't share much yet, but there are a lot of great new products in the development. So next year will be a big year in terms of new products for other areas that we are not addressing yet, but also new categories that I think our customers are really excited about.

So thank you so much for all the positive work you're doing.

Thank you, Heather.

Okay guys, until next week, keep creating your confidence. I decided to change that dynamic. I couldn't be more excited for what you're going to hear. Start learning and growing. Inevitably something will happen. No one succeeds alone.

You don't stop and look around once in a while.

You could miss it. Come on this journey with me.