In this video Dr. Jane Yoo, a board‑certified dermatologist and Mohs surgeon, provides a clinical overview of Rejuran, a brand‑name injectable built around polydeoxyribonucleotide (PDRN) derived from salmon DNA. She clarifies that Rejuran is not a dermal filler; instead it works at the cellular level by supporting fibroblasts to improve collagen and elastin production, leading to better skin texture, tone, and resilience. Dr. Yoo explains the four main Rejuran formulations—Healer, S, I, and Eye—each with distinct consistencies and target areas, and stresses that product selection should be based on the treatment zone and desired outcome. She reviews the strongest evidence‑based indications: acne scarring, texture irregularities, fine lines (especially periorbital), and under‑eye rejuvenation, noting that results are cumulative over multiple sessions rather than immediate. The regulatory landscape is addressed: Rejuran is manufactured in Korea and its injectable status differs in the United States, making it essential for patients to verify product legality and safety with a qualified provider. Dr. Yoo positions Rejuran alongside exosomes and PRP as complementary skin‑quality treatments, not stand‑alone menu items, and advises that decisions about formulation, depth, and treatment plan should be made by a board‑certified dermatologist, particularly when volume loss or other concerns are present.
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Hi everyone, I'm Dr. Jane Yoo, board-certified dermatologist and Mohs surgeon. If you've seen the term Rejuran all over your For You page, you've probably also seen 100 different explanations for what it actually is, and honestly, most of them aren't quite right. Today I'm going to tell you exactly what Rejuran is, what it does, what it doesn't do, and this is the part most other videos skip. whether you can actually get it here in the US. So first, what exactly is Rejuran? Rejuran is a brand name for a treatment built around an ingredient called PDRN, which stands for polydeoxyribonucleotide. It's a purified DNA fragment most commonly derived from salmon, and it's actually been used in wound healing for decades before anyone thought to inject it into the skin. Here's the key thing to understand. Rejuran is not a filler. It doesn't add volume the way something like Juvederm or Restylane does. Instead, it works at the cellular level. It supports your fibroblasts, the cells that produce your collagen and elastin, and it helps your skin's own repair process work better. So if it's not adding volume, what is it doing? What is it actually doing? Think of it this way: a filler is like adding stuffing to a couch cushion. It physically fills a space. Rejuran is more like repairing the cushion's fabric itself so it holds up better and looks healthier over time. That's why people describe Rejuran results as improved texture, better tone, and more resilient skin, rather than saying, oh, my cheeks look fuller. The goal isn't to add volume or change the shape of your face, it's to improve how the skin itself looks and feels. And that's also why Rejuran is marketed so heavily around the glass skin look, because glass skin is fundamentally about smooth texture, even tone, and overall skin quality. Now, something that gets left out of the conversation around Rejuran is that Rejuran isn't just one product. There are actually several formulations designed for different areas and concerns. Rejuran Healer is the original and the one most people are familiar with. It's generally used across the face to improve overall skin quality. Rejuran-S has a thicker consistency and is typically used in areas where more targeted support is needed. Rejuran-I is a thinner formulation designed for more delicate areas of the face. And then there's Rejuran Eye, which is specifically designed for the thin, delicate skin around the eyes. Think more along the lines of improving fine lines, texture, and crepiness rather than adding volume like an under-eye filler would. So these products aren't necessarily interchangeable. A provider should be choosing the formulation based on the area being treated and what you're actually trying to improve, rather than using the same Rejuran product everywhere. So what is it actually good for? In the clinical literature, the strongest use cases include acne scarring and texture irregularities. This is honestly where the most dramatic improvement occurs over a series of treatments, as well as things like overall skin texture and tone, fine lines, especially around the eyes, and under-eye rejuvenation, specifically with Rejuran Eye. One thing I want to be really clear about: this is not an instant transformation treatment. If you're picturing a single session and walking out with completely different skin, that's not how this works. Results build over a series of treatments. It's a slower, more cumulative process, which honestly tracks with the fact that it's working on your skin's actual biology, not just filling space. Okay, this is the section I think matters most. And it's the one most influencer content just glosses over. Rejuran is manufactured in Korea, and its regulatory status for injectable use here in the US is different from its status in Korea. I bring this up not to scare anyone off, but because I see patients pretty regularly who traveled to Korea, got a procedure done there, and came back with questions, sometimes complications, that really could have been avoided with information going in. Whatever you're considering, whatever product, ask your provider directly, what exactly is this, where does it come from, and what's its status here? That matters more for your safety than the ingredient itself. Rejuran belongs to the same skin quality treatment category as exosomes and PRP, but with its own distinct mechanism. And honestly, in practice, I These aren't competing choices. A lot of my patients need more than one of these working together, especially if they're dealing with both volume loss and skin quality issues, which is incredibly common, especially post-weight loss. I want to say this clearly: this is not a treatment to self-select off a menu. Which formulation, how deep, how many sessions, whether it's even the right call for what your skin actually needs, versus, say, Sculptra or a device-based approach, that's a clinical decision. If you're curious whether Rejuran is right for you, talk to a board-certified dermatologist.
