Robert Lustig, MD: How Fructose Fuels Fatty Liver, Oxidative Stress, and Metabolic Disease #fructose
Lecture segment explains how fructose metabolism contributes to intracellular reactive oxygen species (ROS). Dr. Lustig describes multiple ROS sources (Maillard reaction, visceral-fat-derived cytokines activating NADPH oxidase, and mitochondrial dysfunction), antioxidants that neutralize ROS (glutathione, vitamin E) located in peroxisomes, and how overwhelmed antioxidant capacity lets ROS damage the endoplasmic reticulum, triggering the unfolded protein response (ER stress).
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