Dr. Ron Najafi discusses how Ozempic and similar GLP-1 drugs work in the brain to reduce cravings and appetite. They lower dopamine activation in the nucleus accumbens and have shown promise reducing alcohol consumption in some studies, addressing a clinical need since obesity causes severe illness and death.
Chapters
What is the latest on Ozempic? And Ozempic like drugs? I personally know several people on Ozempic. I know their companies that are producing Ozempics. Their stock is going through the roof.
So from a clinician standpoint, look, I'm happy they're here because people need them. And, you know, people are dying from obesity and its complications. Those who are most affected need the most help. From a scientist standpoint, the question is, why do they work? It is true that they have effects on the brain to reduce craving. And that's actually one of the reasons why they have now found that these GLP1 analogs seem to reduce alcohol consumption because they're reducing craving. They're reducing dopamine activation of the nucleus accumbens. And that sounds good, and it very well may be a good thing. And it's probably a very good thing for some people.