Robert Lustig, MD: The 3 Types of Fat Fueling Insulin Resistance and Disease #insulin resistance

7 May 2025 · 1 min
0:57

Robert Lustig explains how subcutaneous fat drives insulin resistance. When obesity increases, fat tissue secretes cytokines like TNF-alpha that travel to the liver, triggering hepatic insulin resistance and higher blood glucose, which forces the pancreas to pump out more insulin in a self-reinforcing cycle.

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