respiratory fitness and acid base regula

PDF · 26 Nov 2025

This article by Peter M. Litchfield, Ph.D. describes CapnoLearning, an approach using capnography and behavioral learning principles to identify and retrain learned breathing behaviors that compromise respiratory chemistry and acid-base balance. It explains physiological bases (Henderson-Hasselbalch equation, PaCO₂/ETCO₂ ranges, Bohr effect), defines behavioral hypocapnia with numeric ETCO₂ thresholds, catalogs symptoms linked to hypocapnia, presents a clinical case illustrating assessment and biofeedback-based retraining, and discusses efficacy and literature foundations.

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Peter M. Litchfield, Ph.D.; published in Psychophysiology Today, 2010, Vol. 7, No. 1.

Approximately 35–45 mmHg (target eucapnic respiration ~35–40 mmHg in training).

ETCO₂ readings below 35 mmHg: 30–35 mmHg mild–moderate, 25–30 mmHg serious, 20–25 mmHg severe.

Plasma pH normal range 7.35–7.45.

Total atmospheric pressure 760 mmHg; PO₂ ≈159 mmHg (20.93%); ambient PCO₂ ≈0.3 mmHg (<0.04%).

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