Dr. Joshua John-Ram Schacter says regenerative therapies like stem cell injections work better when estrogen and testosterone are balanced. Low testosterone in men and menopause in women predict worse outcomes and higher risk of joint stiffness after treatment.
Chapters
If we don't have enough estrogen and testosterone in the system, particularly for women who start with a stiff joint, you're going to be at much greater risk for developing a stiff joint afterwards.
If we think about using biologic systems, if we think about using your own blood or your own bone marrow or your own fat cells or even, you know, stem cells from somebody else, if we're going to inject those into a joint that's healthy and optimized, you know, it makes sense that those are going to do much better. And it's borne out in what we see in our own clinic. When we do our complete metab work with a patient and they do regenerative therapies, it's much more effective than if they choose only to focus on the joint, especially if they have some of these metabolic syndromes, I mean, diabetes and menopause and andropause for men. And when we have testosterone levels that are very low in a man, they don't respond as optimally to our treatments as we'd like. And hey, surgeons, guess what? Your surgeries are at risk for failure. You know, if we don't have enough estrogen and testosterone in the system, particularly for women who start with a stiff joint, you're going to be at much greater risk for developing a stiff joint joint afterwards.