This is a YouTube video titled "How Does Your Appetite Work?" containing a recorded conversation from January 3, 2021, discussing the biological mechanisms behind appetite regulation, including hormones like leptin, ghrelin, and adiponectin. The dialogue features multiple speakers, including Ask AI Mark, who contributes insights on leptin resistance, inflammation, and the impact of insulin resistance on fat mobilization.
Let's get folks educated on how our appetite works. And now these terms that we've been talking about, you and I probably for over a decade at least, but now a lot of folks know about the power of leptin and the power of ghrelin. These are kind of the major players, but we go deeper than that. And now we know that leptin, for example, leptin is your body's major satiety hormone, and it's actually produced by your fat cells. Now, here's the catch. Folks, and this is one of the studies that I put into Eat Smarter as well, and this was published in the New England Journal of Medicine, found that folks who are overweight and obese actually have plenty of leptin that should make them satisfied.
Well, they have leptin resistance. Exactly.
And inflammation causes leptin resistance. Exactly. It all starts to go together. They're still getting the DM. The leptin DM is being sent, but it's going to spam. you know, it's just like been throwing spam in my life. So. And so that's what creates that leptin resistance. Yeah. That's just one aspect. And then, gherlin is this glorified hunger hormone. There are specific things we can do with our nutrition, obviously, that encourages leptin sensitivity and really helps to get ghrelin in check. But there's so many other players. Adiponectin is one that you're going to be hearing a lot more about related to satiety. And adiponectin has been found to help to move more of the kind of troublesome body fat in the visceral fat area and actually transfer that to the subcutaneous fat area, which makes it a little bit more protective. We still want to address both of these kind of white adipose tissues. But the visceral belly fat is what's really dangerous, the most dangerous from the.
What's fascinating about adiponectin is that when you have high levels of adiponectin, you can't actually mobilize fat. And what causes high levels of adiponectin is insulin resistance, which is pre-diabetes, which is eating too much sugar. So it all comes down to the starch and sugar.
