When you drink, your liver can't process alcohol fast enough, so blood alcohol rises. As it falls, glutamate and cortisol rebound, triggering anxiety and fatigue. Alcohol blocks a hormone that controls water retention, causing dehydration and electrolyte loss. Your blood sugar crashes too, leaving you shaky. Even moderate drinking stresses your liver, brain, gut, kidneys, heart, and muscles.
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Hangovers are your body's emergency cleanup after a chemical storm. Well, once your liver can't metabolize ethanol fast enough, then your blood alcohol concentration rises, moving from buzz to drunk. Now the buzz fades and often is followed by rebounding glutamate and cortisol activity, leading to anxiety and fatigue. That's called hangxiety. Even moderate drinking can impact nearly every organ system in the body. Alcohol blocks this hormone in your brain called ADH, or antidiuretic hormone. Why is that a problem? Well, when you are not preventing yourself from peeing, you're going to pee more and you're going to lose So alcohol basically makes you pee more and lose water and electrolytes. Also, you get blood sugar fluctuations. After this insulin surge, your glucose crashes and you can get shaky and fatigued. Alcohol taxes every major system in your body, especially your liver, your brain, your gut, your kidneys, your heart, and your muscles.