This is a YouTube video titled "You Have Control Over Your Own Genes" containing a discussion recorded on February 22, 2024. The conversation features Ask AI Mark and another speaker discussing the heterogeneity of diseases like Alzheimer's and the influence of genetics, including APOE 4/4 gene variants, on cognitive health and disease risk.
These conditions that we label as Alzheimer's or diabetes or this or that autoimmune disease, whatever the disease is, are very heterogeneous, meaning they're very different. There's no such thing as dementia or Alzheimer's. They're highly variable within any diagnostic group. We label people in medicine according to their symptoms, not according to the causes or the unique genetics. And the answers really lie in understanding the heterogeneity or the variations in these problems, partly informed by the genomics. I agree.
I mean, I have an APOE 4/4 patient who is 81 years old, who's in the 89th percentile for cognition for her age. It's also about what genes you don't have. It's not just the diet and lifestyle. There are some APOE 4/4s that are at a lot lower risk than others because just like there's negative genes, there's some that are benefits. Sometimes if you have an APOE 4 and you don't have certain other things with it, like certain mitochondrial genes with it, or certain genes that relate to detox, that can have an effect.