Tesamorelin's Effects Beyond Visceral Fat

16 Aug 2026 · 1 min

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1:27

In this explanatory segment, the speaker reviews a 2020 Mass General Hospital study and a 12‑month clinical trial showing that tesamorelin markedly reduces liver fat—by about 37% after a year of treatment. The reduction is linked to activation of growth‑hormone‑releasing‑hormone (GHRH) receptors, which up‑regulates the master mitochondrial biogenesis factor PGC‑1α, leading to new mitochondria formation and increased fatty‑acid oxidation. The speaker also notes that tesamorelin down‑regulates inflammatory cytokines produced by visceral fat, thereby improving hormonal health. Finally, the segment highlights emerging evidence that tesamorelin can lessen neuroinflammation and boost prefrontal cortex activity, translating into better executive function and memory in older adults.

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Back in 2020, researchers at Mass General Hospital noticed that Tesamorelin had crazy good effects at reducing liver fat. And did you know that having a fat liver is worse for you than having visceral fat? Well, these researchers took samples of their patients' livers before and after giving them Tesamorelin. They knew there was a reason to do this at the beginning of the study. And after 12 months, The participants given tesamorelin had a 37% reduction in fatty liver deposits. But the reason was because inducing those GHRH receptors flipped the master switch of mitochondrial biogenesis. It's called PGC-1 alpha, and that turned on the production of new mitochondria and increased fatty acid oxidation. In all of this research, we've actually learned that tesamorelin has the ability to downregulate inflammatory cytokines, Or signals, which visceral fat is notorious for producing. Make visceral fat less inflammatory, and you're doing a lot of good for your hormonal health. Tessa Morelin has even been shown to improve cognitive deficits in people, turning down neuroinflammation while turning up the activity center of the prefrontal cortex here, which was shown to help with executive function and memory in a study done on older adults.