Lindsey BurwellThe Natural Peptides · The Biohacked Solutions

Why Your Skin Is the Better Delivery System

20 Jul 2026 · 1 min

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In this segment, Lindsey Burwell explains why transdermal drug delivery is a powerful alternative to oral administration. She describes how, after learning about the first‑pass effect, she discovered that delivering medication through the skin allows the drug to enter the bloodstream directly, bypassing the gastrointestinal tract and liver. This avoids first‑pass metabolism entirely, offering a more efficient route that leverages the skin—the body’s largest organ—while noting that the method has a long scientific history.

So this is where transdermal delivery is so powerful. When I learned about the first pass effect and I was searching for what could be next, transdermal delivery was an option that was really powerfully written back by science. That's actually been around a really long time and works very differently because transdermal delivery, it works with the largest organ of your body, and that is your skin. And basically it enters the body through the skin, right into the bloodstream. It bypasses the gut, it bypasses the liver, and has no first pass effect at all.