1,25 hydroxy vitamin D is an immune suppressant Why 1
Short excerpt from a YouTube video by Dr. Ron Najafi (uploaded June 7, 2024). The speaker states that 24-hydroxylase is highly expressed in inflammatory cells (macrophages and inflamed tissue) and inactivates vitamin D. The speaker hypothesizes that active vitamin D (1,25-dihydroxyvitamin D) acts as an immune suppressant, binding to toll-like receptor 4 to attenuate inflammatory cascades.
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