Large buoyant LDL do not cause heart disease, it is the small dense LDL that are problematic
A short YouTube monologue by Dr. Ron Najafi asserting that large, buoyant LDL particles are cardiovascularly neutral and not causative for heart disease, while small, dense LDL particles are atherogenic. The speaker claims small dense LDL are triglyceride-rich remnants after lipid offloading at adipocytes, are small and dense so they leave laminar flow, penetrate under endothelial cells, and contribute to foam cell and plaque formation.
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