Robert Lustig: Chronic vs. Acute Stress—How Cortisol Drives Fat Accumulation and Health Risks
The speaker cites Hans Selye (1951) to distinguish acute versus chronic stress responses. Neuropeptide Y (co-secreted with norepinephrine) binds the Y2 receptor on adipocytes, promoting preadipocyte proliferation and differentiation into adipocytes and increasing lipid storage—counteracting adrenergic effects. Chronic stress also elevates cortisol, which increases visceral fat accumulation, appetite, and lipogenesis.
Questions this video answers
Hans Selye, 1951.
The Y2 receptor.
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