Robert Lustig: Glycogen vs. Fructose—How Fructose Overwhelms Mitochondria and Harms the Liver #nafld
Lecture by Robert Lustig contrasting glycogen and fructose metabolism. Using Von Gierke (glycogen storage disease type 1a) as an example, Lustig notes that excessive glycogen storage is not directly hepatotoxic, whereas dietary fructose is metabolized toward the mitochondria where it can overwhelm oxidative capacity and harm the liver.
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