Robert Lustig: How Sugar is Slowly “Browning” Your Body and Accelerating the Aging Process #aging
Robert Lustig (talk) claims that an ongoing biochemical "browning" process (protein glycation/AGE formation) progressively 'browns' human tissues and accelerates aging; it cannot be stopped except by death but can be slowed. He illustrates with images (newborn vs. 88-year cartilage) and outlines the glycation mechanism that produces hemoglobin A1C (lysine ε-amino reacting with glucose to form a Schiff base that decomposes into a covalent linkage, cleared by the spleen ~three months).
Questions this video answers
"Epsilon amino group of lysine at position 1 binds to the aldehyde at position 1 of glucose, forms the Schiff base which spontaneously decomposes to form this covalent linkage (hemoglobin A1C)."
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