Dr. Robert Lustig explains how losing just 5% of body weight preferentially burns visceral belly fat and improves metabolic health. When you exercise or face acute stress, norepinephrine activates fat cells to release free fatty acids, which travel to your liver and convert to ketones.
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When you, when you lose weight, you lose belly fat first. That's why your waist circumference goes down. And everyone knows that if you just lose 5% of your weight, you will improve your metabolic health. That's been shown 50 ways from Sunday, because fat you're releasing is your visceral fat. Everybody also knows that fat, visceral fat is responsive to adrenergic stimulation. You have acute stress, whether it be exercise or English test, doesn't matter. You get increased norepinephrine. The norepinephrine binds to the beta 3 adrenergic receptor on the fat cell, which causes lipolysis because it activates hormone sensitive lipase, which causes triglyceride to break up into free fatty acids plus glycerol. And then that lipolysis leads to free fatty acids entering the bloodstream, which then go to the liver. And the liver can turn those into ketones. So.