Robert Lustig, MD: Methylglyoxal Can Be Detoxified by an Enzyme Called Glyoxalase-1
Short clip of Dr. Robert Lustig (recorded Nov 19, 2023) explaining that methylglyoxal (MGO) is detoxified by the enzyme glyoxalase-1 (GLO1), whose levels vary genetically between people. He reports measured metabolic effects: D-lactate was 52% higher in their obese patients; in a pediatric study where fructose was replaced with glucose, D-lactate fell by 38% within 10 days. Lustig states that fructose is converted to MGO, which inhibits AMP-activated protein kinase (AMPK), promoting de novo lipogenesis, gluconeogenesis, and cholesterol synthesis.
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52% higher.
D-lactate decreased by 38% in 10 days.
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