Robert Lustig, MD: What Are NAD and NAD-P?
Lecture excerpt by Robert Lustig explaining that NAD and NADP are distinct cofactors used by different enzymes, each reduced (NAD→NADH, NADP→NADPH) before they can be re-oxidized. He notes that reactive oxygen species produced by the electron transport chain can alter the balance of reduction between NAD and NADP, thereby affecting mitochondrial function.
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