Robert Lustig: Preventing Metabolic Syndrome: A Call for Lifestyle Changes and Public Health Action
Robert Lustig argues that metabolic syndrome can be prevented (not merely treated) by addressing environmental/lifestyle drivers. He states that ultra-processed foods and chemical obesogens alter cellular redox potential and increase reactive oxygen species (ROS), which create a misleading signal of energy sufficiency. These altered redox/ROS signals are transported between cells via the circulation, producing organ-specific dysfunction — e.g., increased hepatic gluconeogenesis and increased pancreatic insulin secretion — driving hyperinsulinemia, hyperlipidemia, and increased appetite.
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