Robert Lustig: Similar Pathways of Alcohol and Fructose in Fatty Liver Disease Development
A short interview transcript in which Robert Lustig explains how alcohol (ethanol) and fructose follow similar hepatic metabolic pathways that lead to non-alcoholic fatty liver disease. Lustig describes ethanol conversion to acetaldehyde (via alcohol dehydrogenase), then to acetate which enters mitochondria, overwhelms them, and drives de novo lipogenesis; he also notes fructose enters the liver via the GLUT5 transporter and prompts a related metabolic sequence (discussion continues).
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