Robert Lustig:Sugar Is a Mitochondrial Toxin-Fructose, Making Up 50%, Is the Key Culprit #fattyliver
Robert Lustig (speaking in a YouTube video) argues that fructose inhibits mitochondrial beta-oxidation in the liver by inhibiting three enzymes: AMP kinase, ACADL (acyl-CoA dehydrogenase, long chain), and CPT1A (carnitine palmitoyltransferase 1A). He contrasts this with glucose, which he says activates two enzymes that increase beta-oxidation, and concludes that "sugar is a mitochondrial toxin."
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