Robert Lustig explains how excess sugar triggers a chain reaction: misfolded insulin leads to insulin resistance, which causes the liver to accumulate fat and eventually fail. Since drugs can't fix the receptor, he recommends cutting sugar, eating fiber, and getting choline to reduce what the liver has to process.
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And what happens is you don't fold your insulin chains right, so you end up with insulin deficiency or you don't fold your insulin receptor right, so you end up with insulin resistance. Bottom line is you end up with cell metabolic dysfunction, cell death. In addition, you have lots of acyl COA coming out right because of the de novo lipogenesis. So you end up with either a lipid droplet or insulin resistance because of defects of post translational signaling at the level of the insulin receptor. Take a look at that schema that I just showed you. Where's the drug target? There is none. No drug target. There's no place to fix that. The only thing you can do is you can reduce the substrate availability. That's get rid of the sugar, reduce the hepatic flux. That can happen in the intestine with fiber reducing how much sugar goes to the liver, improve the transport choline and increase the clearance.