Robert Lustig: The Metabolic Fate of Starch vs. Sugar—How Fructose Alters Energy Pathways
Robert Lustig discusses a UCSF study (Michael Pickens, Jackie Marr's lab at San Francisco General) that tested McD rats with either methionine and choline sufficient or deficient conditions and exposed them to diets of starch, glucose, or sucrose/fructose. In methionine/choline-deficient rats, sugar (glucose/sucrose/fructose) — but not starch — produced marked hepatocellular death (TUNEL staining). Lustig links these findings to an observed cohort of 43 children with liver problems to explore whether a similar mechanism may explain pediatric liver disease.
Questions this video answers
43 children.
Michael Pickens at UCSF in Jackie Marr's lab at San Francisco General.
McD rats.
Methionine and choline deficiency (versus sufficient).
Starch, glucose, and sucrose (fructose).
Chapters
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