Robert Lustig: Three Hits to the Liver, Including De Novo Lipogenesis and More
Robert Lustig argues that the established "two-hit" theory of fatty liver disease is incorrect and proposes a "three-hit" model. He identifies the first hit as de novo lipogenesis driven by mitochondrial dysfunction (linking back to prior discussion of mitochondrial problems) and frames the topic with a clinical anecdote about Reye syndrome to emphasize severity.
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