Robert Lustig explains how obesogenic chemicals disrupt the endocrine system across adipose tissue, pancreas, liver, and brain. These chemicals activate transcription factors that alter cellular metabolism, and changes during early life can become permanent.
Chapters
You can see here, okay, this is intake, and this one is what kind of food. And you can see China is a big issue also. Why do these work? Well, there are different places where these obesogens could be affecting endocrine hormonal communication and metabolism, could be occurring at the fat cell itself, could be occurring at the pancreas, occurring at the liver, could be occurring in the GI tract, it could be occurring in the brain. And the reason is because there are a whole bunch of transcription factors that, that respond to these different chemicals to alter cellular metabolism. And in many cases, those changes in cellular metabolism never go away. So when they happen early on, they're fixed. So here are adipose tissue transcription factors, and you can see the agonists that promote it. Here are. Sorry, that's all adipose tissue. And here are hormones. And you can see the different tissues that, that promotes.