Robert Lustig:Why Measuring Insulin, Not Just Glucose = Key to Metabolic Health #metabolicdisorders
Robert Lustig argues that measuring insulin (and specifically proinsulin) is important for assessing metabolic health. He explains cheap assays often detect proinsulin — a precursor that is only about 5% as active as mature insulin — so laboratories may report elevated insulin that actually reflects hyperproinsulinemia. He challenges guideline advice (ADA) against drawing fasting insulin by noting fasting insulin correlates with metabolic health rather than body mass, and that obesity and metabolic health are not perfectly aligned (some obese people can be metabolically healthy and some thin people metabolically unhealthy).
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5% as active as insulin.
January 27, 2025.
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