The most famous destroy of tight junction is Glutin in patients with Celiac disease
Short excerpt from a YouTube video by Dr. Ron Najafi discussing how tight junctions in the gut are ATP-dependent (active process maintained by mitochondria). The speaker claims fructose acts as a mitochondrial toxin that depletes ATP, which may loosen tight junctions, allow peptides to pass through the gut barrier, and possibly trigger food-allergy immune responses. The clip is a conversational explanation rather than a literature review.
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