Dr. David Perlmutter presents data linking ultra-processed foods to Alzheimer's risk: each daily serving raises risk by 13%, while ten or more servings correlates with roughly 300% higher risk. Ultra-processed diets trigger insulin resistance and inflammation that reprogram brain immune cells to damage synapses and neurons.
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For every 1 serving of ultra-processed foods per day, that means 1 handful of chips, 1 flavored yogurt, risk of Alzheimer's increased by 13%. For those individuals consuming 10 or more servings per day, which is incredibly common here in America, 60% of calories coming from ultra-processed foods. So risk for Alzheimer's, a disease for which we have no meaningful pharmaceutical treatment, was increased by 300%. That's a powerful relationship. Does it prove causality? It does not. It's a relationship. But again, now that we understand immunometabolism, we know that that type of diet threatens metabolism, sets us up for metabolic issues like insulin resistance, elevated blood sugar, inflammation, increased body fat, which is so prevalent, and how that affects the brain's immune system. We get it. Because when we shift those immune cells by challenging them metabolically, when we shift them away from being supportive M2 to being destructive or the evil twin M1, those Those M1 brain immune cells are destroying our synapses, they're threatening our neurons, and they're breaking down the blood-brain barrier. All of these things are what goes on in Alzheimer's and in other neurodegenerative conditions.