GLP-1s Are Helping Women Lose Weight — But Are They Costing You Muscle? with Michelle Sirmons, RD

24 Feb 2026 · 44 min
44:25

In this interview Brigid Titgemeier talks with registered dietitian and functional medicine practitioner Michelle Sirmons about the use of GLP‑1 medications for weight loss, especially in women over 40. They explain that while GLP‑1s can lower A1C, they often cause blood‑sugar swings, appetite suppression, and nutrient deficiencies that can lead to cortisol‑driven catabolism, inflammation, and loss of lean muscle. The conversation outlines a comprehensive nutrition strategy to counteract these effects: stabilizing blood glucose with balanced macronutrients at every meal, prioritizing high‑quality protein (~30 g per meal) to protect muscle, increasing fiber (≥30 g/day) and resistant starch to boost short‑chain fatty acids and endogenous GLP‑1 production, and adding omega‑3s and specific amino acids (glutamine, arginine) that further stimulate GLP‑1 secretion. They stress mindful eating—slow chewing and a relaxed, parasympathetic state—to improve digestion and hormone response. Practical tools include regular tracking of biomarkers (A1C, fasting glucose/insulin, lipid panels), body‑composition measurements (DEXA, InBody scans), and symptom logs. The hosts describe their program ecosystem: a 7‑day Blood Sugar Reset to establish foundational habits, the weekly‑recipe Bean Collective membership, and the personalized My Food Is Health coaching that adds deeper testing and individualized plans. Throughout, they share client anecdotes illustrating rapid improvements in energy, mood, cravings, and weight when these protocols are followed, and they emphasize the importance of community, consistency, and organized meal‑planning for busy women.

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