Brigid Titgemeier explains how falling estrogen during menopause triggers insulin resistance and inflammation, shifting where your body stores fat and raising cholesterol. The changes feel like old diet tricks stop working, but lifestyle and medical interventions can change the outcome.
So estrogen is an anti-inflammatory, and it helps your body handle blood sugar and improve your insulin sensitivity. So as it's dropping in perimenopause and menopause, both insulin resistance and inflammation can worsen, which is why it feels like what used to work is no longer working. So as women are going through especially late perimenopause and post-menopause, you'll see cardiovascular risk factors change a lot of times because of these changes that are happening with estrogen dropping, abdominal fat mass increasing, and lean mass actually decreasing. Now, that doesn't mean that that is your destiny, but if you're not making any changes, then that is the most likely seen outcomes. And that will impact fat oxidation. It also increases dyslipidemia, meaning increases in cholesterol and other factors related to cardiovascular health.
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