Josh HeverlyOnline Health & Fitness Coach & Founder at Holistic Hev

85% of human diseases come from two things

4 Sept 2026 · 2 min

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1:31

In this video, the speaker summarizes Dr. Fabian Garcia’s book, arguing that roughly 85% of human diseases are driven by two inter‑related conditions: chronic inflammation and hyperinsulinemia. Both conditions are traced back to two upstream factors—leaky gut and the consumption of refined carbohydrates. The common molecular link is zonulin, a protein found in wheat and other refined carbs that opens tight junctions in the intestinal lining, creating gut permeability. This leaky gut triggers systemic inflammation, while the carbohydrate‑induced insulin spikes exacerbate hyperinsulinemia. The speaker concludes that eliminating refined carbs (bread, pasta, cookies, bagels, etc.) can reduce zonulin exposure, repair gut integrity, lower insulin levels, diminish inflammation, and consequently improve health, body composition, and overall well‑being.

Chapters

85% of human diseases come from 2 things, and those 2 things come from 2 things as well, and those 2 things stem from one thing. So you'd think that if we wanted to fix 85% of human diseases, we would start with this one thing that just cascades into the next. That would be the logical thing to do. Instead, what modern medicine tells us to do is let's just put a pill right here and just put a Band-Aid over this disease. So I just finished reading this book by Dr. Fabian Garcia called F Those Pills, and he genuinely lays it out so, so clearly. It just makes so much sense now. And he states that the 2 main things that cause 85% of diseases are chronic inflammation and hyperinsulinemia, and those 2 are caused by leaky gut and refined carbs. And those 2 things have one thing in common— that's zonulin. Zonulin is a protein that causes holes in the gut, and it's in all refined carbs, all wheat. So when it causes those holes in the gut, it causes inflammation throughout the whole body. And those refined carbs that zonulin comes in, that's insulin. So basically what he's What he's saying is that zonulin that comes in refined carbs spikes your insulin and it causes the holes in your gut, causing leaky gut. And that leaky gut causes incredible inflammation. So in short, if you avoid refined carbs— bread, pasta, cookies, bagels, etc.— you can avoid zonulin, you can help repair your gut and help lower the overall insulin in your body. So basically, by just avoiding refined carbs, you fast-track your way to lower your inflammation, help fix your leaky gut, help fix your insulin, help fix your inflammation. And on top of all that, it'll help you get leaner, look better, and just feel your absolute best.